Small trees or shrubs , to 3 m. Bark gray-brown, smooth. Branchlets glabrous to densely pubescent. Leaf blade ovate, mostly 2-4(-6) × 2-2.5(-3) cm, base obtuse to nearly truncate, margins crenate, apex acute; surfaces abaxially and adaxially harshly pubescent with conspicuous pustules; venation prominent, raised abaxially, reticulate. Flowers: calyx pink to white. Fruits pink, 2-2.5 mm diam.

Flowering late winter-spring (Mar-Apr), sometimes summer-fall (Jul-Nov). Disturbed areas along margins of woodlands and roadways; 0-25 m; Fla.; West Indies.

Trema lamarckiana is endemic to the Florida Keys and West Indies.